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If key change is required on Windows 2008 R2, the following procedure from elevated command prompt will do the trick:

  1. Open a command prompt and change working directory to System32 directory
  2. Type in slmgr.vbs -ckms (this clears and KMS entry you may have)
  3. Type slmgr.vbs -upk (this removes any product key installed)
  4. Type slmgr.vbs -ipk xxxxx-xxxxx-xxxxx-xxxxx-xxxxx (where the x’s is the product key you wish to use)
  5. Type slmgr.vbs -ato (this activates the server)